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Bioactive phenolic amides from Celtis africana.

Areej Mohammad Al-Taweel | Shagufta Perveen | Azza Muhammed El-Shafae | Ghada Ahmed Fawzy | Abdul Malik | Nighat Afza | Lubna Iqbal | Mehreen Latif
Molecules (Basel, Switzerland) | 2012

Nine compounds have been isolated for the first time from Celtis africana, namely trans-N-coumaroyltyramine (1), trans-N-feruloyltyramine (2), trans-N-caffeoyltyramine (3), lauric acid (4), oleic acid (5), palmitic acid (6), lupeol (7), β-sitosterol (8) and oleanolic acid (9), respectively. Their structures have been elucidated by different spectroscopic techniques. The isolated compounds were screened for their antioxidant, anti-inflammatory and acetylcholinestrease enzyme inhibitory activities. Compounds 1-3 showed significant antioxidant and anti-inflammatory activities and weak to moderate acetylcholinestrease enzyme inhibition activity.

Pubmed ID: 22391601

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WI (tool)

RRID:RGD_13508588

Rattus norvegicus with name WI from RGD.

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