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Publication

The ganglioside antigen G(D2) is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting.

S Kailayangiri | B Altvater | J Meltzer | S Pscherer | A Luecke | C Dierkes | U Titze | K Leuchte | S Landmeier | M Hotfilder | U Dirksen | J Hardes | G Gosheger | H Juergens | C Rossig
British journal of cancer | 2012

Novel treatment strategies are needed to cure disseminated Ewing sarcoma. Primitive neuroectodermal features and a mesenchymal stem cell origin are both compatible with aberrant expression of the ganglioside antigen G(D2) and led us to explore G(D2) immune targeting in this cancer.

Pubmed ID: 22374462

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