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Publication

EGCG enhances the therapeutic potential of gemcitabine and CP690550 by inhibiting STAT3 signaling pathway in human pancreatic cancer.

Su-Ni Tang | Junsheng Fu | Sharmila Shankar | Rakesh K Srivastava
PloS one | 2012

Signal Transducer and Activator of Transcription 3 (STAT3) is an oncogene, which promotes cell survival, proliferation, motility and progression in cancer cells. Targeting STAT3 signaling may lead to the development of novel therapeutic approaches for human cancers. Here, we examined the effects of epigallocathechin gallate (EGCG) on STAT3 signaling in pancreatic cancer cells, and assessed the therapeutic potential of EGCG with gemcitabine or JAK3 inhibitor CP690550 (Tasocitinib) for the treatment and/or prevention of pancreatic cancer.

Pubmed ID: 22348037

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: R01 CA114469
  • Agency: NCI NIH HHS, United States
    Id: R01CA114469
  • Agency: NCI NIH HHS, United States
    Id: R01CA125262
  • Agency: NCI NIH HHS, United States
    Id: R01CA125262-02S1
  • Agency: NCI NIH HHS, United States
    Id: R01 CA125262

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PANC-1 (tool)

RRID:CVCL_0480

Cell line PANC-1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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AsPC-1 (tool)

RRID:CVCL_0152

Cell line AsPC-1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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