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Parallel evolution under chemotherapy pressure in 29 breast cancer cell lines results in dissimilar mechanisms of resistance.

Bálint Tegze | Zoltán Szállási | Irén Haltrich | Zsófia Pénzváltó | Zsuzsa Tóth | István Likó | Balázs Gyorffy
PloS one | 2012

Developing chemotherapy resistant cell lines can help to identify markers of resistance. Instead of using a panel of highly heterogeneous cell lines, we assumed that truly robust and convergent pattern of resistance can be identified in multiple parallel engineered derivatives of only a few parental cell lines.

Pubmed ID: 22319589

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NCCN (tool)

RRID:SCR_012959

A not-for-profit alliance of 23 cancer centers devoted to patient care, research, and education, is dedicated to improving the quality, effectiveness, and efficiency of cancer care so that patients can live better lives. Through the leadership and expertise of clinical professionals at NCCN Member Institutions, NCCN develops resources that present valuable information to the numerous stakeholders in the health care delivery system. As the arbiter of cancer care, NCCN promotes the importance of continuous quality improvement and recognizes the significance of creating clinical practice guidelines appropriate for use by patients, clinicians, and other health care decision-makers.

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Genesis (tool)

RRID:SCR_015775

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RRID:CVCL_0062

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MCF-7 (tool)

RRID:CVCL_0031

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