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Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: a resting-state fMRI study.

Wen-bin Guo | Feng Liu | Zhi-min Xue | Xi-jia Xu | Ren-rong Wu | Chao-qiong Ma | Sarah C Wooderson | Chang-lian Tan | Xue-li Sun | Jin-dong Chen | Zhe-ning Liu | Chang-qing Xiao | Hua-fu Chen | Jing-ping Zhao
Progress in neuro-psychopharmacology & biological psychiatry | 2012

Patients with treatment-resistant depression (TRD) and those with treatment-response depression (TSD) respond to antidepressants differently and previous studies have commonly reported different brain networks in resistant and nonresistant patients. Using the amplitude of low-frequency fluctuations (ALFF) approach, we explored ALFF values of the brain regions in TRD and TSD patients at resting state to test the hypothesis of the different brain networks in TRD and TSD patients.

Pubmed ID: 22306865

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SPM (tool)

RRID:SCR_007037

Software package for analysis of brain imaging data sequences. Sequences can be a series of images from different cohorts, or time-series from same subject. Current release is designed for analysis of fMRI, PET, SPECT, EEG and MEG.

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