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Publication

Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE⁻/⁻ mice.

Gillian Douglas | Jennifer K Bendall | Mark J Crabtree | Amy L Tatham | Emma E Carter | Ashley B Hale | Keith M Channon
Cardiovascular research | 2012

Vascular disease states are associated with endothelial dysfunction and increased production of reactive oxygen species derived from NADPH oxidases. However, it remains unclear whether a primary increase in superoxide production specifically in the endothelium alters the initiation or progression of atherosclerosis.

Pubmed ID: 22287576

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Associated grants

  • Agency: Wellcome Trust, United Kingdom
    Id: 090532
  • Agency: British Heart Foundation, United Kingdom
    Id: RG/12/5/29576
  • Agency: British Heart Foundation, United Kingdom
    Id: RG/07/003/23133
  • Agency: British Heart Foundation, United Kingdom
    Id: PG/05/141/20098

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