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Multiple-clade H5N1 influenza split vaccine elicits broad cross protection against lethal influenza virus challenge in mice by intranasal vaccination.

Penghui Yang | Yueqiang Duan | Peirui Zhang | Zhiwei Li | Cheng Wang | Mei Dong | Chong Tang | Li Xing | Hongjing Gu | Zhongpeng Zhao | Xiufan Liu | Shaogeng Zhang | Xiliang Wang
PloS one | 2012

The increase in recent outbreaks and unpredictable changes of highly pathogenic avian influenza (HPAI) H5N1 in birds and humans highlights the urgent need to develop a cross-protective H5N1 vaccine. We here report our development of a multiple-clade H5N1 influenza vaccine tested for immunogenicity and efficacy to confer cross-protection in an animal model.

Pubmed ID: 22279575

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World Health Organization (tool)

RRID:SCR_008505

The directing and coordinating authority responsible for public health within the United Nations system. The WHO Regional Office for Europe (WHO/Europe) is one of the six regional offices around the world. It serves the WHO European Region, which comprises 53 countries from the Atlantic to the Pacific oceans. WHO/Europe collaborates with a range of public health stakeholders in the Region and globally, to ensure that coordinated action is taken to develop and implement efficient health policies and to strengthen health systems. WHO/Europe is made up of public health, scientific, and technical experts.

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BALB/cAnNCrl (tool)

RRID:MGI:2683685

laboratory mouse with name BALB/cAnNCrl from MGI.

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MDCK (tool)

RRID:CVCL_0422

Cell line MDCK is a Spontaneously immortalized cell line with a species of origin Canis lupus familiaris

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