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Publication

Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell help.

Marcus O Butler | Osamu Imataki | Yoshihiro Yamashita | Makito Tanaka | Sascha Ansén | Alla Berezovskaya | Genita Metzler | Matthew I Milstein | Mary M Mooney | Andrew P Murray | Hiroyuki Mano | Lee M Nadler | Naoto Hirano
PloS one | 2012

Using in vivo mouse models, the mechanisms of CD4+ T cell help have been intensively investigated. However, a mechanistic analysis of human CD4+ T cell help is largely lacking. Our goal was to elucidate the mechanisms of human CD4+ T cell help of CD8+ T cell proliferation using a novel in vitro model.

Pubmed ID: 22279573

Research resources used in this publication

None found

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: R01 CA148673-01
  • Agency: NCI NIH HHS, United States
    Id: K22 CA129240
  • Agency: NCI NIH HHS, United States
    Id: R01 CA148673-03
  • Agency: NCI NIH HHS, United States
    Id: R01 CA148673-02
  • Agency: NCI NIH HHS, United States
    Id: R01 CA148673

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A-375 (tool)

RRID:CVCL_0132

Cell line A-375 is a Cancer cell line with a species of origin Homo sapiens (Human)

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K-562 (tool)

RRID:CVCL_0004

Cell line K-562 is a Cancer cell line with a species of origin Homo sapiens (Human)

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