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Publication

Electroacupuncture pretreatment attenuates cerebral ischemic injury through α7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats.

Qiang Wang | Feng Wang | Xin Li | Qianzi Yang | Xuying Li | Ning Xu | Yi Huang | Qiaomei Zhang | Xingchun Gou | Shaoyang Chen | Lize Xiong
Journal of neuroinflammation | 2012

We have previously reported that electroacupuncture (EA) pretreatment induced tolerance against cerebral ischemic injury, but the mechanisms underlying this effect of EA are unknown. In this study, we assessed the effect of EA pretreatment on the expression of α7 nicotinic acetylcholine receptors (α7nAChR), using the ischemia-reperfusion model of focal cerebral ischemia in rats. Further, we investigated the role of high mobility group box 1 (HMGB1) in neuroprotection mediated by the α7nAChR and EA.

Pubmed ID: 22277256

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