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Host genetics and environmental factors regulate ecological succession of the mouse colon tissue-associated microbiota.

Philip Smith | Jay Siddharth | Ruth Pearson | Nicholas Holway | Mark Shaxted | Matt Butler | Natalie Clark | Joanna Jamontt | Robert P Watson | Devika Sanmugalingam | Scott J Parkinson
PloS one | 2012

The integration of host genetics, environmental triggers and the microbiota is a recognised factor in the pathogenesis of barrier function diseases such as IBD. In order to determine how these factors interact to regulate the host immune response and ecological succession of the colon tissue-associated microbiota, we investigated the temporal interaction between the microbiota and the host following disruption of the colonic epithelial barrier.

Pubmed ID: 22272321

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Pipeline Pilot (tool)

RRID:SCR_014917

Software used to automate the process of accessing, analyzing and reporting scientific data. This software can be used by a person with little or no software development experience can create scientific protocols that can be executed through a variety of interfaces including: BIOVIA Web Port, other BIOVIA solutions such as BIOVIA Electronic Lab Notebook, Isentris, Chemical Registration and third-party applications such as Microsoft SharePoint. The protocols aggregate and provide immediate access to volumes of research data, they automate the scientific analysis of data and allow researchers to explore, visualize and report results.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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C57BL/6Smoc-Nod2em1Smoc (tool)

RRID:IMSR_NM-KO-190210

Mus musculus with name C57BL/6Smoc-Nod2em1Smoc from IMSR.

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