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Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia.

Christoph P Hofstetter | Jan-Karl Burkhardt | Benjamin J Shin | Demirkan B Gürsel | Lynn Mubita | Ramana Gorrepati | Cameron Brennan | Eric C Holland | John A Boockvar
PloS one | 2012

The hypoxic microenvironment of glioblastoma multiforme (GBM) is thought to increase resistance to cancer therapies. Recent evidence suggests that hypoxia induces protein phosphatase 2A (PP2A), a regulator of cell cycle and cell death. The effects of PP2A on GBM tumor cell proliferation and survival during hypoxic conditions have not been studied.

Pubmed ID: 22253878

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: K08 CA130985
  • Agency: NCI NIH HHS, United States
    Id: K08CA130985

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Novus Biologicals (tool)

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