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Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes.

Weijuan Shao | Zhiwen Yu | Yuting Chiang | Yi Yang | Tuanyao Chai | Warren Foltz | Huogen Lu | I George Fantus | Tianru Jin
PloS one | 2012

Mechanisms underlying the attenuation of body weight gain and insulin resistance in response to high fat diet (HFD) by the curry compound curcumin need to be further explored. Although the attenuation of the inflammatory pathway is an accepted mechanism, a recent study suggested that curcumin stimulates Wnt signaling pathway and hence suppresses adipogenic differentiation. This is in contrast with the known repressive effect of curcumin on Wnt signaling in other cell lineages.

Pubmed ID: 22253696

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Associated grants

  • Agency: Canadian Institutes of Health Research, Canada

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