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Publication

NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration.

Liya Qin | Fulton T Crews
Journal of neuroinflammation | 2012

Activation of microglia causes the production of proinflammatory factors and upregulation of NADPH oxidase (NOX) that form reactive oxygen species (ROS) that lead to neurodegeneration. Previously, we reported that 10 daily doses of ethanol treatment induced innate immune genes in brain. In the present study, we investigate the effects of chronic ethanol on activation of NOX and release of ROS, and their contribution to ethanol neurotoxicity.

Pubmed ID: 22240163

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Associated grants

  • Agency: NIAAA NIH HHS, United States
    Id: AA007573
  • Agency: NIAAA NIH HHS, United States
    Id: AA019767
  • Agency: NIAAA NIH HHS, United States
    Id: AA11605
  • Agency: NIAAA NIH HHS, United States
    Id: AA020022
  • Agency: NIAAA NIH HHS, United States
    Id: AA020024
  • Agency: NIAAA NIH HHS, United States
    Id: R28 AA012725
  • Agency: NIAAA NIH HHS, United States
    Id: R24 AA012725
  • Agency: NIAAA NIH HHS, United States
    Id: AA020023

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RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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