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Assisted reproductive technologies include in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). It has been shown that embryos derived from ART have higher rates of aneuploidy. Although the majority of ART pregnancies are genetically normal, it is suspected that aneuploid embryos may persist as mosaics and lead to confined placental mosaicism (CPM). Due to the greater risks of sperm aneuploidy in infertile men, CPM may be more prevalent in ICSI than IVF pregnancies. In this report, we investigated the prevalence of CPM in IVF and ICSI pregnancies using comparative genomic hybridization and flow cytometry.
Pubmed ID: 22239762
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