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Low efficacy of single-dose albendazole and mebendazole against hookworm and effect on concomitant helminth infection in Lao PDR.

Phonepasong Ayé Soukhathammavong | Somphou Sayasone | Khampheng Phongluxa | Vilavanh Xayaseng | Jürg Utzinger | Penelope Vounatsou | Christoph Hatz | Kongsap Akkhavong | Jennifer Keiser | Peter Odermatt
PLoS neglected tropical diseases | 2012

Albendazole and mebendazole are increasingly deployed for preventive chemotherapy targeting soil-transmitted helminth (STH) infections. We assessed the efficacy of single oral doses of albendazole (400 mg) and mebendazole (500 mg) for the treatment of hookworm infection in school-aged children in Lao PDR. Since Opisthorchis viverrini is co-endemic in our study setting, the effect of the two drugs could also be determined against this liver fluke.

Pubmed ID: 22235353

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