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SimTB, a simulation toolbox for fMRI data under a model of spatiotemporal separability.

Erik B Erhardt | Elena A Allen | Yonghua Wei | Tom Eichele | Vince D Calhoun
NeuroImage | 2012

We introduce SimTB, a MATLAB toolbox designed to simulate functional magnetic resonance imaging (fMRI) datasets under a model of spatiotemporal separability. The toolbox meets the increasing need of the fMRI community to more comprehensively understand the effects of complex processing strategies by providing a ground truth that estimation methods may be compared against. SimTB captures the fundamental structure of real data, but data generation is fully parameterized and fully controlled by the user, allowing for accurate and precise comparisons. The toolbox offers a wealth of options regarding the number and configuration of spatial sources, implementation of experimental paradigms, inclusion of tissue-specific properties, addition of noise and head movement, and much more. A straightforward data generation method and short computation time (3-10 seconds for each dataset) allow a practitioner to simulate and analyze many datasets to potentially understand a problem from many angles. Beginning MATLAB users can use the SimTB graphical user interface (GUI) to design and execute simulations while experienced users can write batch scripts to automate and customize this process. The toolbox is freely available at http://mialab.mrn.org/software together with sample scripts and tutorials.

Pubmed ID: 22178299

Research resources used in this publication

None found

Antibodies used in this publication

None found

Associated grants

  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB000840-08
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB000840-03
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB005846
  • Agency: NCRR NIH HHS, United States
    Id: NIH 1 P20 RR021938-01
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB000840-06
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB000840
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB000840-05
  • Agency: NCRR NIH HHS, United States
    Id: P20 RR021938
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB000840-09
  • Agency: NIBIB NIH HHS, United States
    Id: NIH 1R01-EB006841
  • Agency: NIBIB NIH HHS, United States
    Id: NIH 1R01-EB005846
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB000840-04
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB020407
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB000840-02
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB000840-01
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB006841
  • Agency: NIBIB NIH HHS, United States
    Id: NIH 2R01-EB000840
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB000840-07

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