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It is important for ion channel peptides to have energetic stability and ion-selectivity for development of some medicines. In the present study, our objective was to achieve formation of energetically stable and ion-selective channels in the membrane using cyclic tetrapeptides. We succeeded in formation of energetically stable and ion-selective channels using two cyclic tetrapeptides cyclo(D-Ala-Dap)(2) (Dap; l-2,3-diaminopropionic acid) and cyclo(D-Ala-Glu)(2). The results of ion channel recording suggested that the cationic cyclo(D-Ala-Dap)(2) was resulted in Cl(-) anion-selective and the anionic cyclo(D-Ala-Glu)(2) led to K(+) cation-selective ion channel formation, respectively. This ion selectivity may be attributed to the charge state of peptides. And a low-hydrophobic cyclic tetrapeptide; cyclo(D-Ala-Dap)(2) had a tendency to form stable ion channel compared to more high-hydrophobic ones; cyclo(D-Phe-Lys)(2), cyclo(D-Phe-Dap)(2) and cyclo(D-Ala-Lys)(2). Our findings will shed light on the field of ion channel peptide study, especially cyclic one.
Pubmed ID: 22172312
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Software suite for electrophysiology data acquisition and analysis by Molecular Devices. Used for the control and recording of voltage clamp, current clamp, and patch clamp experiments. The software suite consists of Clampex 11 Software for data acquisition, AxoScope 11 Software for background recording, Clampfit 11 Software for data analysis, and optional Clampfit Advanced Analysis Module for sophisticated and streamlined analysis.
View all literature mentionsA software tool which provides a means to acquire and analyze time-series data, as well as a direct route to publication quality graphics. It provides a variety of graph styles and automated, extended, and/or customizable analyses.
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