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Publication

Quinpirole elicits differential in vivo changes in the pre- and postsynaptic distributions of dopamine D₂ receptors in mouse striatum: relation to cannabinoid-1 (CB₁) receptor targeting.

Diane A Lane | June Chan | Megan L Fitzgerald | Chris S Kearn | Ken Mackie | Virginia M Pickel
Psychopharmacology | 2012

The nucleus accumbens (Acb) shell and caudate-putamen nucleus (CPu) are respectively implicated in the motivational and motor effects of dopamine, which are mediated in part through dopamine D₂-like receptors (D₂Rs) and modulated by activation of the cannabinoid-1 receptor (CB₁R). The dopamine D(₂/D3) receptor agonist, quinpirole elicits internalization of D₂Rs in isolated cells; however, dendritic and axonal targeting of D₂Rs may be highly influenced by circuit-dependent changes in vivo and potentially influenced by endogenous CB₁R activation.

Pubmed ID: 22160162

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Associated grants

  • Agency: NIDA NIH HHS, United States
    Id: DA005130
  • Agency: NIDA NIH HHS, United States
    Id: P60 DA005130
  • Agency: NIMH NIH HHS, United States
    Id: MH40342
  • Agency: NIDA NIH HHS, United States
    Id: R01 DA011322
  • Agency: NIDA NIH HHS, United States
    Id: DA04600
  • Agency: NIMH NIH HHS, United States
    Id: R37 MH040342
  • Agency: NIDA NIH HHS, United States
    Id: DA021696
  • Agency: NIDA NIH HHS, United States
    Id: K05 DA021696
  • Agency: NIDA NIH HHS, United States
    Id: R01 DA004600
  • Agency: NIMH NIH HHS, United States
    Id: R01 MH040342
  • Agency: NIDA NIH HHS, United States
    Id: P50 DA005130
  • Agency: NIDA NIH HHS, United States
    Id: DA011322

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