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Selective inhibition of intra-alveolar p55 TNF receptor attenuates ventilator-induced lung injury.

Szabolcs Bertok | Michael R Wilson | Peter J Morley | Ruud de Wildt | Andrew Bayliffe | Masao Takata
Thorax | 2012

Tumour necrosis factor (TNF) is upregulated in the alveolar space early in the course of ventilator-induced lung injury (VILI). Studies in genetically modified mice indicate that the two TNF receptors play opposing roles during injurious high-stretch mechanical ventilation, with p55 promoting but p75 preventing pulmonary oedema.

Pubmed ID: 22156959

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Associated grants

  • Agency: Wellcome Trust, United Kingdom
    Id: 081208

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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