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Publication

Krüppel-like factor 4 is induced by rapamycin and mediates the anti-proliferative effect of rapamycin in rat carotid arteries after balloon injury.

Ying Wang | Beilei Zhao | Yi Zhang | Zhihui Tang | Qiang Shen | Youyi Zhang | Weizhen Zhang | Jie Du | Shu Chien | Nanping Wang
British journal of pharmacology | 2012

The transcription factor, Krüppel-like factor 4 (KLF4), plays an important role in regulating the proliferation of vascular smooth muscle cells. This study aimed to examine the effect of rapamycin on the expression of KLF4 and the role of KLF4 in arterial neointimal formation.

Pubmed ID: 22017667

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Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL106579

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