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Publication

Preclinical development of CAT-354, an IL-13 neutralizing antibody, for the treatment of severe uncontrolled asthma.

R D May | P D Monk | E S Cohen | D Manuel | F Dempsey | N H E Davis | A J Dodd | D J Corkill | J Woods | C Joberty-Candotti | L A Conroy | F Koentgen | E C Martin | R Wilson | N Brennan | J Powell | I K Anderson
British journal of pharmacology | 2012

IL-13 is a pleiotropic Th2 cytokine considered likely to play a pivotal role in asthma. Here we describe the preclinical in vitro and in vivo characterization of CAT-354, an IL-13-neutralizing IgG4 monoclonal antibody (mAb), currently in clinical development.

Pubmed ID: 21895629

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