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Molecular epidemiology of the SH (small hydrophobic) gene of human respiratory syncytial virus (HRSV), over 2 consecutive years.

Hildenêr Nogueira Lima | Viviane Fongaro Botosso | Danielle Bruna Leal Oliveira | Angélica Cristine de Almeida Campos | Andrea Lima Leal | Tereza Souza Silva | Patrícia Alves Ramos Bosso | Claudia Trigo Pedroso Moraes | Claudionor Gomes da Silva Filho | Sandra Elisabete Vieira | Alfredo Elias Gilio | Klaus Eberhard Stewien | Edison Luiz Durigon
Virus research | 2012

Human respiratory syncytial virus (HRSV) strains were isolated from nasopharyngeal aspirates collected from 965 children between 2004 and 2005, yielding 424 positive samples. We sequenced the small hydrophobic protein (SH) gene of 117 strains and compared them with other viruses identified worldwide. Phylogenetic analysis showed a low genetic variability among the isolates but allowed us to classify the viruses into different genotypes for both groups, HRSVA and HRSVB. It is also shown that the novel BA-like genotype was well segregated from the others, indicating that the mutations are not limited to the G gene.

Pubmed ID: 21893117

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PAUP (tool)

RRID:SCR_014931

Software which creates phylogenetic trees from molecular, morphological and/or behavioral data through high speed computer analysis.

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