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Publication

Chronic HO-1 induction with cobalt protoporphyrin (CoPP) treatment increases oxygen consumption, activity, heat production and lowers body weight in obese melanocortin-4 receptor-deficient mice.

E Csongradi | J M Docarmo | J H Dubinion | T Vera | D E Stec
International journal of obesity (2005) | 2012

Heme oxygenase-1 induction (HO-1) elicits chronic weight loss in several rodent models of obesity. Despite these findings, the mechanism by which HO-1 induction reduces body weight is unclear. Chronic HO-1 induction does not alter food intake, suggesting other mechanisms such as increases in metabolism and activity may be responsible for the observed reduction of body weight. In this study, we investigated the mechanism of weight loss elicited by chronic HO-1 induction in a model of genetic obesity due to melanocortin-4 receptor (MC4R) deficiency.

Pubmed ID: 21467998

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Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: P01 HL051971
  • Agency: NHLBI NIH HHS, United States
    Id: P01 HL051971-19
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL088421
  • Agency: NHLBI NIH HHS, United States
    Id: P01HL-51971

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SigmaStat (tool)

RRID:SCR_010285

Software tool for data graphing and analysis by Systat Software, Inc.

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C57BL/6J (tool)

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Mus musculus with name C57BL/6J from IMSR.

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C57BL/6J (tool)

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