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Publication

Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice.

Hong Guo | Daozhong Jin | Yuanyuan Zhang | Wendy Wright | Merlijn Bazuine | David A Brockman | David A Bernlohr | Xiaoli Chen
Diabetes | 2010

Lipocalin (LCN) 2 belongs to the lipocalin subfamily of low-molecular mass-secreted proteins that bind small hydrophobic molecules. LCN2 has been recently characterized as an adipose-derived cytokine, and its expression is upregulated in adipose tissue in genetically obese rodents. The objective of this study was to investigate the role of LCN2 in diet-induced insulin resistance and metabolic homeostasis in vivo.

Pubmed ID: 20332347

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK080743-01
  • Agency: NIDDK NIH HHS, United States
    Id: R01DK080743
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK080743-03
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK080743-02
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK080743-02S2
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK050456
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK080743

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