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Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors.

Bijay S Jaiswal | Vasantharajan Janakiraman | Noelyn M Kljavin | Jeffrey Eastham-Anderson | James E Cupp | Yuxin Liang | David P Davis | Klaus P Hoeflich | Somasekar Seshagiri
PloS one | 2009

Oncogenic RAS is a highly validated cancer target. Attempts at targeting RAS directly have so far not succeeded in the clinic. Understanding downstream RAS-effectors that mediate oncogenesis in a RAS mutant setting will help tailor treatments that use RAS-effector inhibitors either alone or in combination to target RAS-driven tumors.

Pubmed ID: 19492075

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