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Alexander disease is a rare disorder of the central nervous system with characteristic symmetric white matter abnormalities with frontal predominance on magnetic resonance (MR) images. Histopathology shows a lack of myelin in the affected white matter, variably interpreted as hypomyelination or demyelination. To increase our insight into the nature of the pathology leading to the MR imaging findings in Alexander disease, we applied serial MR imaging, spectroscopy, magnetization transfer (MT) imaging (MTI), and diffusion tensor imaging (DTI) in six patients with juvenile Alexander disease.
Pubmed ID: 19484233
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Software for automatic quantification of in vivo proton MR spectra. Though it is mainly used for brain analysis, it can be used for a variety of analyses in different areas of the body. It receives time-domain data as input and gives a one page summary output. It is fully automatic, non-interactive, and operator-independent.
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