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Concatenated multitype L2 fusion proteins as candidate prophylactic pan-human papillomavirus vaccines.

Subhashini Jagu | Balasubramanyam Karanam | Ratish Gambhira | Sudha V Chivukula | Revathi J Chaganti | Douglas R Lowy | John T Schiller | Richard B S Roden
Journal of the National Cancer Institute | 2009

Vaccination with minor capsid protein L2 induces antibodies that cross-neutralize diverse papillomavirus types. However, neutralizing antibody titers against the papillomavirus type from which the L2 vaccine was derived are generally higher than the titers against heterologous types, which could limit effectiveness against heterologous types. We hypothesized that vaccination with concatenated multitype L2 fusion proteins derived from known cross-protective epitopes of several divergent human papillomavirus (HPV) types might enhance immunity across clinically relevant HPV genotypes.

Pubmed ID: 19470949

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P50 CA098252
  • Agency: NCI NIH HHS, United States
    Id: CA118790

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293TT (tool)

RRID:CVCL_1D85

Cell line 293TT is a Transformed cell line with a species of origin Homo sapiens (Human)

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BALB/cAnNCrl (tool)

RRID:MGI:2683685

laboratory mouse with name BALB/cAnNCrl from MGI.

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