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Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase.

Inna E Tchivileva | Andrea G Nackley | Li Qian | Sean Wentworth | Matthew Conrad | Luda B Diatchenko
Molecular pain | 2009

Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain. Specifically, low COMT activity is associated with heightened pain perception and development of musculoskeletal pain in humans as well as increased experimental pain sensitivity in rodents.

Pubmed ID: 19291302

Research resources used in this publication

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Associated grants

  • Agency: NIDCR NIH HHS, United States
    Id: R01 DE016558
  • Agency: NICHD NIH HHS, United States
    Id: K12 HD052191

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TFSEARCH: Searching Transcription Factor Binding Sites (tool)

RRID:SCR_004262

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ImageQuant (tool)

RRID:SCR_014246

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