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A model of traumatic brain injury occurring in a laboratory in which an insult inflicted by a pendulum striking the piston of a reservoir of fluid to generate a fluid pressure pulse to the intact dura through a craniotomy, which is made either centrally around the midline, or laterally over the parietal bone, between bregma and lambda. Typically injuries produced are diffuse-like pathology, neurobehavioral deficits, BBB disruption, and axonal injury.
Fluid percussion injury model catalog total records: 15 View All
Synonyms: Fluid percussion injury, FPI
Model Common Data Element (CDE): Method used to asses the level of responsiveness prior to injury induction, Time between end of surgery and injury induction, Placment of cap inside or outside of craniectomy, Cap material type, Left/Right/Centre location of craniectomy, Conector Tube Inner Diamaeter, Presence or absence of a motor seizure, Inner diameter of cap
Species: mouse, rat, pig
Assessments: modified Neurological Severity Score (mNSS), qRT-PCR, Western blot, Brain water content, Oxidative Stress Evaluation, Caspase activity assays, Cavalieri probe method, Conditioned freezing response test, Counting APC-positive cells, Counting NeuN-positive cells, Histology, Immunohistochemistry, Object recognition test, Quantification of TrkA phosphorylation, Western blot analysis, cell counts, immunocytochemistry, kainate sensitivity test, microglia activation, myelin loss, paw placement test, High-resolution mass spectrometry imaging, MALDI-MS imaging, electrophysiological recordings, Morris water maze (MWM), Hidden Platform, Probe Trial, Visible Platform, Novel object recognition test, Y-Maze Test, Novel object location test, qPCR, Compound action potential (CAP) recording, Immunohistochemistry (IHC), optical density, Diffusion Tensor Imaging scan, Neurological Severity Score (NSS), up-down method, von Frey filament, DNIC assessment, Cardiac output, Cerebral blood flow, renal blood flow, Doppler imaging, Pulsed wave Doppler measurements, Transesophageal echocardiography, blood gas, central venous pressure, intracranial pressure monitor, Magnetic resonance imaging (MRI), Agilent 2200 TapeStation assay, DEX, LTP assessment, NanoString nCounter analysis, open field test, Paired-pulse ratio, Trace fear conditioning, Y-maze task, electrophysiological assessment, CNN-based segmentation maps, Loss Function, hippocampus segmentation task, skull-stripping task, Cell Morphology, Neurological Severity Score, Olmos amino cupric silver (Ag) technique, Rotarod, Sleep recordings, forced swim task, morphology analysis, novel object recognition, open field task
De Feo R, Manninen E, Chary K, Hämäläinen E, Immonen R, Andrade P, Ndode-Ekane XE, Gröhn O, Pitkänen A, Tohka J. Hippocampal position and orientation as prognostic biomarkers for posttraumatic epileptogenesis: An experimental study in a rat lateral fluid percussion modelEpilepsia. 2022 Apr 22. doi: 10.1111\/epi.17264. Online ahead of print. PMID:35451496
Chen Y, Lu Y, Xu S, Liu M, Chen W, Zhang Y, Wei L, Zhong C. HDAC1 expression is positively correlated with NADPH oxidase 4-mediated oxidative stress in a mouse model of traumatic brain injuryJ Neurophysiol. 2022 May 1;127(5):1438-1444. doi: 10.1152\/jn.00049.2022. Epub 2022 Apr 20. PMID:35443136
Bray CE, Witcher KG, Adekunle-Adegbite D, Ouvina M, Witzel M, Hans E, Tapp ZM, Packer J, Goodman E, Zhao F, Chunchai T, O'Neil S, Chattipakorn SC, Sheridan J, Kokiko-Cochran ON, Askwith C, Godbout JP. Chronic Cortical Inflammation, Cognitive Impairment, and Immune Reactivity Associated with Diffuse Brain Injury Are Ameliorated by Forced Turnover of MicrogliaJ Neurosci. 2022 May 18;42(20):4215-4228. doi: 10.1523\/JNEUROSCI.1910-21.2022. Epub 2022 Apr 19. PMC9121837 PMID:35440489
Irvine KA, Peters CM, Vazey EM, Ferguson AR, Clark D. DREADD-mediated activation of the locus coeruleus restores descending nociceptive inhibition after traumatic brain injury in ratsJ Neurotrauma. 2022 Apr 12. doi: 10.1089\/neu.2021.0485. Online ahead of print. PMID:35412843
Gupta A, Dovek L, Proddutur A, Elgammal FS, Santhakumar V. Long-Term Effects of Moderate Concussive Brain Injury During Adolescence on Synaptic and Tonic GABA Currents in Dentate Granule Cells and Semilunar Granule CellsFront Neurosci. 2022 Mar 14;16:800733. doi: 10.3389\/fnins.2022.800733. eCollection 2022. PMC8964009 PMID:35360164
Tapp ZM, Cornelius S, Oberster A, Kumar JE, Atluri R, Witcher KG, Oliver B, Bray C, Velasquez J, Zhao F, Peng J, Sheridan J, Askwith C, Godbout JP, Kokiko-Cochran ON. Sleep fragmentation engages stress-responsive circuitry, enhances inflammation and compromises hippocampal function following traumatic brain injuryExp Neurol. 2022 Jul;353:114058. doi: 10.1016\/j.expneurol.2022.114058. Epub 2022 Mar 28. PMC9068267 PMID:35358498
Adedipe A, John AS, Krishnamoorthy V, Wang X, Steck DT, Ferreira R, White N, Stern S. Left Ventricular Function in the Initial Period After Severe Traumatic Brain Injury in SwineNeurocrit Care. 2022 Mar 21. doi: 10.1007\/s12028-022-01468-5. Online ahead of print. PMID:35314968
Nakuci J, McGuire M, Schweser F, Poulsen D, Muldoon SF. Differential Patterns of Change in Brain Connectivity Resulting from Severe Traumatic Brain InjuryBrain Connect. 2022 May 5. doi: 10.1089\/brain.2021.0168. Online ahead of print. PMID:35302399
De Feo R, Hämäläinen E, Manninen E, Immonen R, Valverde JM, Ndode-Ekane XE, Gröhn O, Pitkänen A, Tohka J. Convolutional Neural Networks Enable Robust Automatic Segmentation of the Rat Hippocampus in MRI After Traumatic Brain InjuryFront Neurol. 2022 Feb 17;13:820267. doi: 10.3389\/fneur.2022.820267. eCollection 2022. PMC8891699 PMID:35250823
Tian Y, Zhao R, Li X, Zhou J, Zhan D, Wang Y, He Y, Zhang J, Yuan H. Alterations of microRNAs expression profiles in small extracellular vesicle after traumatic brain injury in miceExp Anim. 2022 Mar 7. doi: 10.1538\/expanim.21-0148. Online ahead of print. PMID:35249933
Sowers JL, Sowers ML, Shavkunov AS, Hawkins BE, Wu P, DeWitt DS, Prough DS, Zhang K.iScience. 2021 Sep 9;24(10):103108. doi: 10.1016/j.isci.2021.103108. eCollection 2021 Oct 22.10.1016/j.isci.2021.103108 PMID:34622161
Rowe RK, Harrison JL, Morrison HW, Subbian V, Murphy SM, Lifshitz J.J Neurotrauma. 2019 Apr 15;36(8):1318-1334. doi: 10.1089/neu.2018.5980. Epub 2018 Dec 18.10.1089/neu.2018.5980 PMID:30398389
Delbary-Gossart S, Lee S, Baroni M, Lamarche I, Arnone M, Canolle B, Lin A, Sacramento J, Salegio EA, Castel MN, Delesque-Touchard N, Alam A, Laboudie P, Ferzaz B, Savi P, Herbert JM, Manley GT, Ferguson AR, Bresnahan JC, Bono F, Beattie MS.Brain. 2016 Jun;139(Pt 6):1762-82. doi: 10.1093/brain/aww074. Epub 2016 Apr 15.10.1093/brain/aww074 PMID:27084575
Liu Y, Liu Z, Li X, Luo B, Xiong J, Gan W, Jiang M, Zhang Z, Schluesener HJ, Zhang Z.Accumulation of connective tissue growth factor+ cells during the early phase of rat traumatic brain injury.Diagn Pathol. 2014 Jul 10;9:141. doi: 10.1186/1746-1596-9-141. PMID:24927383
Eakin K, Baratz-Goldstein R, Pick CG, Zindel O, Balaban CD, Hoffer ME, Lockwood M, Miller J, Hoffer BJ.Efficacy of N-acetyl cysteine in traumatic brain injury.PLoS One. 2014 Apr 16;9(4):e90617. doi: 10.1371/journal.pone.0090617. eCollection 2014. PMID:24740427
No protocol has been found from protocols.io
Chou, A., Sangmi Lee, Krukowski, K., Guglielmetti, C., Nolan, A., Hawkins, B., Chaumeil, M., Beattie, M., Bresnahan, J., Rosi, S., & Ferguson, A. (2022). Aggregated animal subject metadata from 11 UCSF preclinical TBI publications and 1 ODC-TBI published dataset (Version 1.0) [Dataset]. Open Data Commons for Traumatic Brain Injury (ODC-TBI). https://doi.org/10.34945/F51P49 DOI:10.34945/F51P49
Sowers, J., Sowers, M., Zhang, K., & Hawkins, B. (2021). Traumatic Brain Injury Induces Region-specific Glutamate Metabolism Changes As Measured by Multiple Mass Spectrometry Methods (Animal Metadata) (Version 1.0) [Dataset]. Open Data Commons for Traumatic Brain Injury (ODC-TBI). https://doi.org/10.34945/F50P40 DOI:10.34945/F50P40
Rowe, R., Lifshitz, J., & Harrison, J. (2023). Motor, cognitive, anxiety-like, and depressive-like behavior following one or two diffuse TBIs in the mouse (Version 1.0) [Dataset]. Open Data Commons for Traumatic Brain Injury (ODC-TBI). https://doi.org/10.34945/F5BS3R DOI:10.34945/F5BS3R
