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A model of traumatic brain injury occurring in a laboratory that is designed to simulate various aspects of complex blast-induced injury scenarios, including open field exposure, blast tubes using explosives, or shock tubes using compressed air or gas.
Blast model catalog total records: 26 View All
Synonyms: blast exposure model, blast injury model, blast injury
Model Common Data Element (CDE): In development - available soon
Species: pig, mouse, rat
Assessments: stress relaxation, Fractional Zener constitutive model, fractional Zener constitutive model, unconfined compression test, L/D emergence task, Enzyme-linked immunosorbent assay (ELISA), Barnes Maze test test, Contextual fear memory testing, Elevated zero maze, Fear conditioning, Immunohistochemistry (IHC), Light dark escape, Locomotor activity, Novel object localization test, Novel object recognition test, Oligomeric Aβ42 dot blot analysis, Social interaction, Sound-attenuated isolation, Behavioral Testing, Thioflavin S staining, social preference test, elevated zero maze apparatus, light/dark emergence task, Electrophysiological recording, Propidium iodideluorescence, Polyunsaturated Fatty Acids analysis, Sphingolipids analysis, Pavlovian fear conditioning, RT-PCR, Sphingomyelinase Assay, electroretinogram recording, open-field behavior assessment, optokinetic reflex measurement, tail suspension test, Image Acquisition, Western blot, Brain water content, cortical oxidative stress, Gel Electrophoresis, Immunoblotting, Liquid-phase isoelectric focusing, Protein Deimination, Tissue IgG, liquid chromatography, mass finger printing, mass of the neutral loss, tandem mass spectrometry, Immunohistochemical, Tomography, Home-cage monitoring, LightSpot test, Spontaneous behaviors, Anxiety-like behaviors, Fractional anisotropy, Heart rate, core temperature, functional Magnetic resonance imaging (MRI), regional heterogeneity, respiration, Calcium imaging, Off chip micro-bead assay, flow cytometry, righting time, Sucrose Preference Test, forced swim test, step down inhibitory avoidance, sucrose preference test, Forced Swim Test, Gait analysis, Passive avoidance, Prepulse Inhibition, righting reflex suppression, Electroretinography, Optomotor response, Spectral domain optical coherence tomography, TUNEL staining, Y-maze, spectral-domain optical coherence tomography, Elevated Plus Maze, Histology, Three-Chamber Sociability Test, open field test, righting reflex timing, rotating pole test, AP firing patterns, AP threshold, Electrophysiological recordings, Input resistance, Resting membrane potential, Spontaneous neuronal activity, action potential generation, fast after-hyperpolarizations, hyperpolarization-activated cation current recordings, infrared-differential interference contrast microscopy, Amyloid burden, Astrocytic end feet contacts estimation, Capillary density estimation, Pericyte estimation, HPLC-ECD methods, changes in free amino acid (FAA) concentrations, Magnetic resonance imaging, Barnes maze, Simple Neuroassessment of Asymmetric impairment (SNAP), TEM, histopathology, immunohistochemistry, light-dark box, myelin sheath defects, nesting behavior tests, open-field, Global and phospho-proteomes, Liquid chromatography-mass spectrometry (LC-MS/MS), Simple Neuroassessment of Asymmetric imPairment (SNAP) test, silver staining, KEGG pathway analysis, STRING network, mEPSCs, home-cage monitoring (HCM), CognitionWall, label-free quantitative proteomics, STRING Protein interaction
Norris C, Weatherbee J, Murphy SF, VandeVord PJ.Neurosci Res. 2024 Jan;198:47-56. doi: 10.1016/j.neures.2023.06.008. Epub 2023 Jun 21.10.1016/j.neures.2023.06.008 PMID:37352935
Muelbl MJ, Glaeser BL, Shah AS, Chiariello RA, Nawarawong NN, Stemper BD, Budde MD, Olsen CM.Repeated blast mild traumatic brain injury and oxycodone self-administration produce interactive effects on neuroimaging outcomesAddict Biol. 2022 Mar;27(2):e13134. doi: 10.1111/adb.13134.PMC889628710.1111/adb.13134 PMID:35229952
Simmons S, Langlois LD, Oyola MG, Gouty S, Wu TJ, Nugent FS. Blast-Induced Mild Traumatic Brain Injury Alterations of Corticotropin-Releasing Factor Neuronal Activity in the Mouse Hypothalamic Paraventricular NucleusFront Synaptic Neurosci. 2022 Jan 27;13:804898. doi: 10.3389\/fnsyn.2021.804898. eCollection 2021. PMC8828487 PMID:35153711
Siedhoff HR, Chen S, Balderrama A, Sun GY, Koopmans B, DePalma RG, Cui J, Gu Z.Long-Term Effects of Low-Intensity Blast Non-Inertial Brain Injury on Anxiety-Like Behaviors in Mice: Home-Cage Monitoring Assessments.Neurotrauma Rep. 2022 Jan 11;3(1):27-38. doi: 10.1089/neur.2021.0063. eCollection 2022. PMID:35141713
Chen S, Siedhoff HR, Zhang H, Liu P, Balderrama A, Li R, Johnson C, Greenlief CM, Koopmans B, Hoffman T, DePalma RG, Li DP, Cui J, Gu Z.Low-intensity blast induces acute glutamatergic hyperexcitability in mouse hippocampus leading to long-term learning deficits and altered expression of proteins involved in synaptic plasticity and serine protease inhibitors.Neurobiol Dis. 2022 Apr;165:105634. doi: 10.1016/j.nbd.2022.105634. Epub 2022 Jan 22. PMID:35077822
Yang Z, Simovic MO, Edsall PR, Liu B, Cancio TS, Batchinsky AI, Cancio LC, Li Y. HMGB1 Inhibition to Ameliorate Organ Failure and Increase Survival in TraumaBiomolecules. 2022 Jan 8;12(1):101. doi: 10.3390\/biom12010101. PMC8773879 PMID:35053249
Clark AT, Abrahamson EE, Harper MM, Ikonomovic MD. Chronic effects of blast injury on the microvasculature in a transgenic mouse model of Alzheimer's disease related Aβ amyloidosisFluids Barriers CNS. 2022 Jan 10;19(1):5. doi: 10.1186\/s12987-021-00301-z. PMC8751260 PMID:35012589
Browne CA, Wulf HA, Jacobson ML, Oyola MG, Wu TJ, Lucki I. Long-term increase in sensitivity to ketamine's behavioral effects in mice exposed to mild blast induced traumatic brain injuryExp Neurol. 2022 Apr;350:113963. doi: 10.1016\/j.expneurol.2021.113963. Epub 2021 Dec 28. PMC8858880 PMID:34968423
Dickerson MR, Murphy SF, Urban MJ, White Z, VandeVord PJ. Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced NeurotraumaFront Behav Neurosci. 2021 Dec 10;15:787475. doi: 10.3389\/fnbeh.2021.787475. eCollection 2021. PMC8703020 PMID:34955781
Perez Garcia G, Perez GM, Otero-Pagan A, Abutarboush R, Kawoos U, De Gasperi R, Gama Sosa MA, Pryor D, Hof PR, Cook DG, Gandy S, Ahlers ST, Elder GA. Transcranial Laser Therapy Does Not Improve Cognitive and Post-Traumatic Stress Disorder-Related Behavioral Traits in Rats Exposed to Repetitive Low-Level Blast InjuryNeurotrauma Rep. 2021 Dec 2;2(1):548-563. doi: 10.1089\/neur.2021.0005. eCollection 2021. PMC8655798 PMID:34901948
Anderson LM, Samineni S, Wilder DM, Lara M, Eken O, Urioste R, Long JB, Arun P. The Neurobehavioral Effects of Buprenorphine and Meloxicam on a Blast-Induced Traumatic Brain Injury Model in the RatFront Neurol. 2021 Oct 12;12:746370. doi: 10.3389\/fneur.2021.746370. eCollection 2021. PMC8545992 PMID:34712199
Mondal K, Takahashi H, Cole J 2nd, Del Mar NA, Li C, Stephenson DJ, Allegood J, Cowart LA, Chalfant CE, Reiner A, Mandal N. Systemic Elevation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Is Associated with Protection against Visual, Motor, and Emotional Deficits in Mice following Closed-Head Mild Traumatic Brain InjuryMol Neurobiol. 2021 Nov;58(11):5564-5580. doi: 10.1007\/s12035-021-02501-y. Epub 2021 Aug 8. PMC8655834 PMID:34365584
Perez Garcia G, De Gasperi R, Tschiffely AE, Gama Sosa MA, Abutarboush R, Kawoos U, Statz JK, Ciarlone S, Reed E, Jeyarajah T, Perez GM, Otero-Pagan A, Pryor D, Hof PR, Cook DG, Gandy S, Elder GA, Ahlers ST. Repetitive Low-Level Blast Exposure Improves Behavioral Deficits and Chronically Lowers Aβ42 in an Alzheimer Disease Transgenic Mouse ModelJ Neurotrauma. 2021 Nov 15;38(22):3146-3173. doi: 10.1089\/neu.2021.0184. Epub 2021 Sep 15. PMC8820291 PMID:34353119
Allen RS, Motz CT, Singh A, Feola A, Hutson L, Douglass A, Ramachandra Rao S, Skelton LA, Cardelle L, Bales KL, Chesler K, Gudapati K, Ethier CR, Harper MM, Fliesler SJ, Pardue MT. Dependence of visual and cognitive outcomes on animal holder configuration in a rodent model of blast overpressure exposureVision Res. 2021 Nov;188:162-173. doi: 10.1016\/j.visres.2021.07.008. Epub 2021 Jul 30. PMC8440444 PMID:34333201
Wang C, Shao C, Zhang L, Siedlak SL, Meabon JS, Peskind ER, Lu Y, Wang W, Perry G, Cook DG, Zhu X. Oxidative Stress Signaling in Blast TBI-Induced Tau PhosphorylationAntioxidants (Basel). 2021 Jun 15;10(6):955. doi: 10.3390\/antiox10060955. PMC8232162 PMID:34203583
Harper MM, Boehme N, Dutca LM, Anderson MG. The Retinal Ganglion Cell Response to Blast-Mediated Traumatic Brain Injury Is Genetic Background DependentInvest Ophthalmol Vis Sci. 2021 Jun 1;62(7):13. doi: 10.1167\/iovs.62.7.13. PMC8196410 PMID:34106210
Rutter B, Song H, DePalma RG, Hubler G, Cui J, Gu Z, Johnson CE.Shock Wave Physics as Related to Primary Non-Impact Blast-Induced Traumatic Brain Injury.Mil Med. 2021 Jan 25;186(Suppl 1):601-609. doi: 10.1093/milmed/usaa290. PMID:33499439
McCarty AK, Zhang L, Hansen S, Jackson WJ, Bentil SA. Viscoelastic properties of shock wave exposed brain tissue subjected to unconfined compression experimentsJ Mech Behav Biomed Mater. 2019 Dec;100:103380. doi: 10.1016\/j.jmbbm.2019.103380. Epub 2019 Aug 8. PMID:31446342
Chen M, Song H, Cui J, Johnson CE, Hubler GK, DePalma RG, Gu Z, Xia W.Proteomic Profiling of Mouse Brains Exposed to Blast-Induced Mild Traumatic Brain Injury Reveals Changes in Axonal Proteins and Phosphorylated Tau.J Alzheimers Dis. 2018;66(2):751-773. doi: 10.3233/JAD-180726. PMID:30347620
Song H, Konan LM, Cui J, Johnson CE, Langenderfer M, Grant D, Ndam T, Simonyi A, White T, Demirci U, Mott DR, Schwer D, Hubler GK, Cernak I, DePalma RG, Gu Z.Ultrastructural brain abnormalities and associated behavioral changes in mice after low-intensity blast exposure.Behav Brain Res. 2018 Jul 16;347:148-157. doi: 10.1016/j.bbr.2018.03.007. Epub 2018 Mar 8. PMID:29526786
Attilio PJ, Flora M, Kamnaksh A, Bradshaw DJ, Agoston D, Mueller GP. The Effects of Blast Exposure on Protein Deimination in the BrainOxid Med Cell Longev. 2017;2017:8398072. doi: 10.1155\/2017\/8398072. Epub 2017 May 24. PMC5463117 PMID:28626499
Chen H, Chan YL, Nguyen LT, Mao Y, de Rosa A, Beh IT, Chee C, Oliver B, Herok G, Saad S, Gorrie C. Moderate traumatic brain injury is linked to acute behaviour deficits and long term mitochondrial alterationsClin Exp Pharmacol Physiol. 2016 Nov;43(11):1107-1114. doi: 10.1111\/1440-1681.12650. PMID:27557565
Ko J, Hemphill MA, Gabrieli D, Wu L, Yelleswarapu V, Lawrence G, Pennycooke W, Singh A, Meaney DF, Issadore D. Smartphone-enabled optofluidic exosome diagnostic for concussion recoverySci Rep. 2016 Aug 8;6:31215. doi: 10.1038\/srep31215. PMC4976377 PMID:27498963
Arun P, Oguntayo S, Albert SV, Gist I, Wang Y, Nambiar MP, Long JB. Acute decrease in alkaline phosphatase after brain injury: A potential mechanism for tauopathyNeurosci Lett. 2015 Nov 16;609:152-8. doi: 10.1016\/j.neulet.2015.10.036. Epub 2015 Oct 19. PMID:26483321
Effgen GB, Vogel EW 3rd, Lynch KA, Lobel A, Hue CD, Meaney DF, Bass CR, Morrison B 3rd. Isolated primary blast alters neuronal function with minimal cell death in organotypic hippocampal slice culturesJ Neurotrauma. 2014 Jul 1;31(13):1202-10. doi: 10.1089\/neu.2013.3227. Epub 2014 May 8. PMID:24558968
Ahmed F, Gyorgy A, Kamnaksh A, Ling G, Tong L, Parks S, Agoston D. Time-dependent changes of protein biomarker levels in the cerebrospinal fluid after blast traumatic brain injuryElectrophoresis. 2012 Dec;33(24):3705-11. doi: 10.1002\/elps.201200299. PMID:23161535
Johnson, C., Cui, J., Zuckerman, A., Song, H., K. Hubler, G., G. DePalma, R., Cernak, I., & Gu, Z. (2022). Open-field blast (OFB) model in mice v1. https://doi.org/10.17504/protocols.io.yxmvm2kwog3p/v1 DOI:10.17504/protocols.io.yxmvm2kwog3p/v1
Zuckerman, A., Siedhoff, H., Balderrama, A., Jiankun Cui, & Gu, Z. (2023). Home-cage monitoring general behavior of C57BL/6J male mice during the CognitionWall test 3 months after open-field LIB exposure (Version 1.0) [Dataset]. Open Data Commons for Traumatic Brain Injury (ODC-TBI). https://doi.org/10.34945/F59W23 DOI:10.34945/F59W23
Norris, C., Murphy, S., VandeVord, P., & Weatherbee, J. (2024). Quantifying acute changes in neurometabolism following blast-induced traumatic brain injury in male Sprague Dawley rats (Version 1.0) [Dataset]. Open Data Commons for Traumatic Brain Injury (ODC-TBI). https://doi.org/10.34945/F5BP43 DOI:10.34945/F5BP43
