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Lazaroid attenuates edema by stabilizing ATPase in the traumatized rat brain.

R Durmaz | G Kanbak | F Akyüz | S Isiksoy | F Yücel | M Inal | E Tel
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques | 2003 May

The aim of the present study was to determine the potential therapeutic value of the lazaroid U-83836E on blood brain barrier (BBB) breakdown and edema with respect to the changes in the synaptosomal Na+/K+ and Mg(2+)/Ca(2+)-adenosinetriphosphatase (ATPase) activities, tissue malondialdehyde levels and the neuronal viability in the rat brain subjected to cerebral trauma.

Pubmed ID: 12774954

TBI Model

  • Weight-drop model
  • Weight-drop method

    • Animal Information

  • Species: rat
  • Strain: Spraque-Dawley
  • Age (weeks): No age reported
  • Weight (grams): 250 - 320

    • Assessments

    BBB disruption, Evans blue, tissue water content, Evans blue content, Lipid peroxide assay, Morphometry, assay of membrane-bound ATPase activities, water content

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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