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NKCC1-mediated traumatic brain injury-induced brain edema and neuron death via Raf/MEK/MAPK cascade.

KT Lu | NC Cheng | CY Wu | YL Yang
Critical care medicine | 2008 Mar

Brain edema is one of the characteristic features of patients with severe traumatic brain injury. The aim of this study was to examine the effects of Na+-K+-2Cl- co-transporter on traumatic brain injury-induced brain edema and neuron damage and to elucidate the relationship between Na+-K+-2Cl- co-transporter and mitogen-activated protein kinase (MAPK) cascade.

Pubmed ID: 18431281

TBI Model

  • Weight-drop model
  • Weight-drop

    • Animal Information

  • Species: rat
  • Strain: Wistar
  • Age (weeks): No age reported
  • Weight (grams): 350 - 400

    • Assessments

    Immunofluorescence Double Labeling, NKCC1 Messenger RNA Assay, Neuron Damage, Water Content Measurement, Western Blot

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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