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AA-861 appears to suppress leukocyte infiltration induced by traumatic brain injury in rats.

R Durmaz | E Kasapoglu | M Vural | Ö Çolak | Y Aydar | C Bal | MA Atasoy
Neurosciences (Riyadh, Saudi Arabia) | 2008 Jul

To study the effect of 2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone (AA-861) on intercellular adhesion molecule 1 (ICAM-1) and P-selectin expression, leukotriene B4 (LTB4) level, and myeloperoxidase (MPO) activity 24 hours after traumatic brain injury (TBI).

Pubmed ID: 21063328

TBI Model

  • Weight-drop model
  • Weight-drop method

    • Animal Information

  • Species: rat
  • Strain: Sprague-Dawley
  • Age (weeks): No age reported
  • Weight (grams): 250 - 350

    • Assessments

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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