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The cerebrovascular and neurological impact of chronic smoking on post-traumatic brain injury outcome and recovery: an in vivo study.

F Sivandzade | F Alqahtani | A Sifat | L Cucullo
Journal of neuroinflammation | 2020 Apr 27

Traumatic brain injury (TBI) is among the most prevalent causes of cerebrovascular and neurological damage worldwide. To this end, tobacco smoke (TS) has been shown to promote vascular inflammation, neurovascular impairments, and risk of cerebrovascular and neurological disorders through oxidative stress (OS) stimuli targeting the blood-brain barrier (BBB) endothelium among others. It has been recently suggested that premorbid conditions such as TS may exacerbate post-TBI brain damage and impact recovery.

Pubmed ID: 32340626

TBI Model

  • Weight-drop model
  • Weight-drop
  • Animal Information

  • Species: mouse
  • Strain: C57BL/6J
  • Age (weeks): 6 - 8
  • Weight (grams): 20 - 22
  • Assessments

    Enzyme-linked immunoassay, Open field test, Western blotting, biochemical, molecular

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available
  • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available