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Systemic inflammatory effects of traumatic brain injury, femur fracture, and shock: an experimental murine polytrauma model.

C Probst | MJ Mirzayan | P Mommsen | C Zeckey | T Tegeder | L Geerken | M Maegele | A Samii | M van Griensven
Mediators of inflammation | 2012

Despite broad research in neurotrauma and shock, little is known on systemic inflammatory effects of the clinically most relevant combined polytrauma. Experimental investigation in an animal model may provide relevant insight for therapeutic strategies. We describe the effects of a combined injury with respect to lymphocyte population and cytokine activation.

Pubmed ID: 22529516

TBI Model

  • Weight-drop model
  • Weight-drop

    • Animal Information

  • Species: mouse
  • Strain: C57BL/J6
  • Age (weeks): 8 - 10
  • Weight (grams): 27.4 - 27.4

    • Assessments

    flow cytometry

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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