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The severity of brain damage determines bone marrow stromal cell therapy efficacy in a traumatic brain injury model.

C Bonilla | M Zurita | L Otero | C Aguayo | MA Rico | J Vaquero
The journal of trauma and acute care surgery | 2012 May

Patients who survive traumatic brain injury (TBI) can undergo serious sensorial and motor function deficits. Once damage occurs, there is no effective treatment to bring patients to full recovery. Recent studies, however, show bone marrow stromal cells (BMSC) as a potential therapy for TBI.

Pubmed ID: 22673246

TBI Model

  • Weight-drop model
  • Weight-drop

    • Animal Information

  • Species: rat
  • Strain: Wistar
  • Age (weeks): No age reported
  • Weight (grams): 225 - 250

    • Assessments

    Immunohistochemical, Neurologic Severity Scores, ematoxylin-eosin staining, hematoxylin-eosin staining

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Contact Us

    Department of Neurosciences, School of Medicine

    University of California, San Diego





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