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Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1β release through the inhibition of Nogo-A expression.

PK Chao | KT Lu | JY Jhu | YY Wo | TC Huang | LS Ro | YL Yang
Journal of neuroinflammation | 2012 Jun 07

Nogo-A is a member of the reticulon family of membrane-associated proteins and plays an important role in axonal remodeling. The present study aimed to investigate alterations in Nogo-A expression following traumatic brain injury (TBI)-induced inflammation and neuronal damage.

Pubmed ID: 22676811

TBI Model

  • Weight-drop model
  • Weight-drop

    • Animal Information

  • Species: rat
  • Strain: Wistar
  • Age (weeks): No age reported
  • Weight (grams): 350 - 400

    • Assessments

    ELISA, H & E staining, Luxol fast blue staining, Nogo-A mRNA assay, RT-PCR, Water content, Western blot analysis

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Contact Us

    Department of Neurosciences, School of Medicine

    University of California, San Diego





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