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Morris water maze function and histologic characterization of two age-at-injury experimental models of controlled cortical impact in the immature rat.

PD Adelson | W Fellows-Mayle | PM Kochanek | CE Dixon
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery | 2013 Jan

Controlled cortical impact (CCI) is commonly used in adult animals to study focal traumatic brain injury (TBI). Our study aims to further study injury mechanisms in children and variable models of pathology in the developing brain.

Pubmed ID: 23089934

TBI Model

  • Controlled cortical impact model

    • Animal Information

  • Species: rat
  • Strain: Sprague-Dawley
  • Age (weeks): 1 - 2.45
  • Weight (grams): 15 - 40

    • Assessments

    Histology, Morris Water Maze (MWM)

    TBI model parameters

  • Impact Depth (mm): 1.5
  • Impact Duration (ms): 500
  • Impact Velocity (m/s): 4
  • Impactor Tip: tip diameter - 3 or 6 mm

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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