Searching across hundreds of databases

Our searching services are busy right now. Please try again later

  • Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Establishing the ferret as a gyrencephalic animal model of traumatic brain injury: Optimization of controlled cortical impact procedures.

SC Schwerin | EB Hutchinson | KL Radomski | KP Ngalula | CM Pierpaoli | SL Juliano
Journal of neuroscience methods | 2017 Jun 15

Although rodent TBI studies provide valuable information regarding the effects of injury and recovery, an animal model with neuroanatomical characteristics closer to humans may provide a more meaningful basis for clinical translation. The ferret has a high white/gray matter ratio, gyrencephalic neocortex, and ventral hippocampal location. Furthermore, ferrets are amenable to behavioral training, have a body size compatible with pre-clinical MRI, and are cost-effective.

Pubmed ID: 28499842

TBI Model

  • Controlled cortical impact model

    • Animal Information

  • Species: ferret
  • Strain: No strain reported
  • Age (weeks): No age reported
  • Weight (grams): No weight reported

    • Assessments

    Adhesive tape detection test, Gait, Immunohistochemistry (IHC), Magnetic resonance imaging (MRI), Novel object recognition test, Open field test

    TBI model parameters

  • Impact Depth (mm): 1 - 4
  • Impact Duration (ms): 100
  • Impact Velocity (m/s): 3 - 5
  • Impactor Tip: tip diameter - 3 mm

    • Device Name

    Impact One™ Stereotaxic Impactor

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

    Recent News Entries

    Contact Us

    Department of Neurosciences, School of Medicine

    University of California, San Diego





    About SciCrunch | Privacy Policy | Terms of Service

    SciCrunch