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Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2.

ND Osier | L Pham | BJ Pugh | A Puccio | D Ren | YP Conley | S Alexander | CE Dixon
Neuroscience letters | 2017 May 22

Traumatic brain injury (TBI) is a devastating and costly acquired condition that affects individuals of all ages, races, and geographies via a number of mechanisms. The effects of TBI on melatonin receptors remain unknown.

Pubmed ID: 28377323

TBI Model

  • Controlled cortical impact model

    • Animal Information

  • Species: rat
  • Strain: Sprague-Dawley
  • Age (weeks): No age reported
  • Weight (grams): No weight reported

    • Assessments

    Bicinchoninic acid (BCA) assay, Western blot

    TBI model parameters

  • Impact Depth (mm): 2.8
  • Impact Duration (ms): 150
  • Impact Velocity (m/s): 4
  • Impactor Tip: tip diameter - 6 mm, tip shape - flat-beveled

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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