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Amelioration of rCBF and PbtO2 following TBI at high altitude by hyperbaric oxygen pre-conditioning.

S Hu | F Li | H Luo | Y Xia | J Zhang | R Hu | G Cui | H Meng | H Feng
Neurological research | 2010 Mar

Hypobaric hypoxia at high altitude can lead to brain damage and pre-conditioning with hyperbaric oxygen (HBO) can reduce ischemic/hypoxic brain injury. This study investigates the effects of high altitude on traumatic brain injury (TBI) and examines the neuroprotection provided by HBO preconditioning against TBI.

Pubmed ID: 20158955

TBI Model

  • Weight-drop model

    • Animal Information

  • Species: rat
  • Strain: Sprague-Dawley
  • Age (weeks): No age reported
  • Weight (grams): 200 - 240

    • Assessments

    Transmission electron microscope analysis, Cerebral Blood Fluid

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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