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Propofol versus isoflurane anesthesia under hypothermic conditions: effects on intracranial pressure and local cerebral blood flow after diffuse traumatic brain injury in the rat.

FS Kahveci | N Kahveci | T Alkan | B Goren | E Korfali | K Ozluk
Surgical neurology | 2001 Sep

The aim of this study was to compare the cerebral protective effects of two known protective anesthetics, isoflurane and propofol, when these were used in combination with moderate hypothermia (33-34 degrees C) after diffuse traumatic brain injury (TBI) in the rat. We assessed cerebral protection by measuring local cerebral blood flow (LCBF), mean arterial blood pressure (MABP), cerebral perfusion pressure (CPP) and intracranial pressure (ICP).

Pubmed ID: 11597656

TBI Model

  • Weight-drop model

    • Animal Information

  • Species: rat
  • Strain: Wistar
  • Age (weeks): No age reported
  • Weight (grams): 275 - 350

    • Assessments

    Intracranial pressure monitoring, Blood gas analysis, Hematocrit testing, Cerebral blood flow

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    University of California, San Diego





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