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Transplantation of olfactory ensheathing cells promotes the recovery of neurological functions in rats with traumatic brain injury associated with downregulation of Bad.

YC Wang | QJ Xia | YC Ba | TY Wang | N LiN | Y Zou | FF Shang | XF Zhou | TH Wang | XM Fu | JG Qi
Cytotherapy | 2014 Jul

The neuroprotective effects of olfactory ensheathing cells (OECs) after transplantation have largely been known in the injured nervous system. However, the underlying mechanisms still must be further elucidated. We explored the effects of OEC transplantation on the recovery of neurophysiologic function and the related anti-apoptosis mechanism in acute traumatic brain injury.

Pubmed ID: 24582457

TBI Model

  • Weight-drop model
  • Modified Feeney Weight-drop model

    • Animal Information

  • Species: rat
  • Strain: Sprague-Dawley
  • Age (weeks): 0.29 - 0.42
  • Weight (grams): 220 - 250

    • Assessments

    Immunohistochemistry (IHC), Neurological Severity Score (NSS), RT-PCR, terminal deoxynucleotidyltransferase-mediated dUTP nick end-labeling

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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