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NADPH oxidase inhibition improves neurological outcome in experimental traumatic brain injury.

XY Lu | HD Wang | JG Xu | K Ding | T Li
Neurochemistry international | 2014 Apr

Traumatic brain injury (TBI) is a worldwide health problem with oxidative stress recognized as a major pathogenetic factor. The present experimental study was designed to explore the neuroprotective effect of NADPH oxidase (NOX) inhibitor, apocynin, on mouse TBI.

Pubmed ID: 24589771

TBI Model

  • Weight-drop model
  • Modified Weight-drop model

    • Animal Information

  • Species: mouse
  • Strain: ICR
  • Age (weeks): No age reported
  • Weight (grams): 28 - 32

    • Assessments

    Evans blue (EB) extravasation, TUNEL assay, Western blot

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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