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Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury.

HT Zhu | C Bian | JC Yuan | WH Chu | X Xiang | F Chen | CS Wang | H Feng | JK Lin
Journal of neuroinflammation | 2014 Mar 27

Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that contributes to substantial neuronal damage and behavioral impairment, and Toll-like receptor 4 (TLR4) is an important mediator of thiscascade. In the current study, we tested the hypothesis that curcumin, a phytochemical compound with potent anti-inflammatory properties that is extracted from the rhizome Curcuma longa, alleviates acute inflammatory injury mediated by TLR4 following TBI.

Pubmed ID: 24669820

TBI Model

  • Weight-drop model
  • Feeney's Weight-drop contusion model

    • Animal Information

  • Species: mouse
  • Strain: C57BL/6
  • Age (weeks): 8 - 10
  • Weight (grams): 20 - 25

    • Assessments

    Cytotoxicity assay, Enzyme-linked immunosorbent assay (ELISA), Fluoro-Jade B, Immunofluorescence, TUNEL staining, Western blot analysis, modified Neurological Severity Score, wet/dry method

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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