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Co-grafting of neural stem cells with olfactory en sheathing cells promotes neuronal restoration in traumatic brain injury with an anti-inflammatory mechanism.

SJ Liu | Y Zou | V Belegu | LY Lv | N Lin | TY Wang | JW McDonald | X Zhou | QJ Xia | TH Wang
Journal of neuroinflammation | 2014 Apr 02

We sought to investigate the effects of co-grafting neural stem cells (NSCs) with olfactory ensheathing cells (OECs) on neurological behavior in rats subjected to traumatic brain injury (TBI) and explore underlying molecular mechanisms.

Pubmed ID: 24690089

TBI Model

  • Weight-drop model

    • Animal Information

  • Species: rat
  • Strain: Sprague-Dawley
  • Age (weeks): No age reported
  • Weight (grams): 180 - 220

    • Assessments

    RT-PCR, TUNEL staining, immunoenzyme-linked immunocytochemistry, immunofluorescence staining, modified Neurological Severity Score (mNSS)

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Contact Us

    Department of Neurosciences, School of Medicine

    University of California, San Diego





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