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A novel traumatic brain injury model for induction of mild brain injury in rats.

T Ghadiri | M Sharifzadeh | F Khodagholi | SM Modarres Mousavi | G Hassanzadeh | MR Zarrindast | A Gorji
Journal of neuroscience methods | 2014 Aug 15

Due to the marked heterogeneity of human traumatic brain injury (TBI), none of the available animal model can reproduce the entire spectrum of TBI, especially mild focal TBI. This study was designed to develop a modified TBI weight drop model for induction of focal mild cerebral injury.

Pubmed ID: 24906055

TBI Model

  • Weight-drop model

    • Animal Information

  • Species: rat
  • Strain: Wistar
  • Age (weeks): No age reported
  • Weight (grams): 230 - 300

    • Assessments

    Nissl and TTC stained, Nissl staining, lesion volume, modified Neurologic Severity Score, open field behavioral test, western blot analysis

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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