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Mild traumatic brain injury-induced hippocampal gene expressions: The identification of target cellular processes for drug development.

D Tweedie | L Rachmany | DS Kim | V Rubovitch | E Lehrmann | Y Zhang | KG Becker | E Perez | CG Pick | NH Greig
Journal of neuroscience methods | 2016 Oct 15

Neurological dysfunction after traumatic brain injury (TBI) poses short-term or long-lasting health issues for family members and health care providers. Presently there are no approved medicines to treat TBI. Epidemiological evidence suggests that TBI may cause neurodegenerative disease later in life. In an effort to illuminate target cellular processes for drug development, we examined the effects of a mild TBI on hippocampal gene expression in mouse.

Pubmed ID: 26868732

TBI Model

  • Weight-drop model
  • Animal Information

  • Species: mouse
  • Strain: ICR
  • Age (weeks): No age reported
  • Weight (grams): 30 - 40
  • Assessments

    Gene expression, Ingenuity Pathway Analysis tool, Gene Set Enrichment analysis

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available
  • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available