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Therapeutic effects of eugenol in a rat model of traumatic brain injury: A behavioral, biochemical, and histological study.

J Barot | B Saxena
Journal of traditional and complementary medicine | 2021 Jul

Traumatic brain injury (TBI) results in death or long term functional disabilities. Eugenol is demonstrated to be beneficial in a range of experimental models of neurological disorders via its anti-inflammatory and antioxidant properties. Thus, the present study was designed to investigate the neuroprotective effects of eugenol in a weight-drop induced rat model of TBI.

Pubmed ID: 34195026

TBI Model

  • Weight-drop model
  • Modified Marmarou's Weight-drop model

    • Animal Information

  • Species: rat
  • Strain: Sprague-Dawley
  • Age (weeks): 8 - 12
  • Weight (grams): 350 - 450

    • Assessments

    Histology, Image analysis, Morris Water Maze (MWM)

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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