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The Protective Effect of Omeprazole Against Traumatic Brain Injury: An Experimental Study.

R Özay | ME Türkoğlu | B Gürer | H Dolgun | O Evirgen | Bİ Ergüder | N Hayırlı | L Gürses | Z Şekerci
World neurosurgery | 2017 Aug

The development of secondary brain injury via oxidative stress after traumatic brain injury (TBI) is a well-known entity. Consequently, the aim of the present study was to evaluate the role of omeprazole (OM) on rat model of TBI.

Pubmed ID: 28461271

TBI Model

  • Weight-drop model

    • Animal Information

  • Species: rat
  • Strain: Wistar Albino
  • Age (weeks): No age reported
  • Weight (grams): 250 - 300

    • Assessments

    Histology, Lowry method, Tissue Caspase-3 Analysis, Tissue Glutathione Peroxidase Analysis, Tissue Malondialdehyde Analysis, Tissue Nitric Oxide Analysis, Tissue Superoxide Dismutase Analysis

    TBI model parameters

  • Impact Depth (mm): No information available
  • Impact Duration (ms): No information available
  • Impact Velocity (m/s): No information available
  • Impactor Tip: No information available

    • Device Name

    No information available

    Associated Datasets

    No information available

    Associated Protocols

    No information available

    About

    The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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    Department of Neurosciences, School of Medicine

    University of California, San Diego





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